Attention!
The PharmaGenes Essentials genetic test may only be carried out under medical supervision. This means that customers can only order the test directly through their doctor and the results will be sent to the doctor.
MITO partners who are doctors will soon find a webinar with more detailed information in our MITOcare Academy.
MITOcare Diagnostics
The genetic test to determine medication metabolism
With the PharmaGenes Essentials genetic test from MITOcare Diagnostics, doctors finally have a tool at hand to analyze a patient's medication metabolism.
A complex algorithm is used to analyze 22 genetic variants with an influence on medication metabolism. This profile contains genes that are involved in the metabolism of various medicines and can therefore help with substrate selection and dosage. The genetics of the following medication groups are being investigated: Blood pressure medications, antiarythmics, antiplatelet agents, antidepressants, antipsychotics, amphetamines, antiemetics, barbiturates, corticoids and many more.
Based on these results, the doctor can adapt the medication for the analyzed patient to their individual medication metabolism. In addition, based on the results, an emergency passport is issued in haptic form (pharmaceutical passport), which can also be given to the patient.
All the information in the analysis is easy to understand and clearly visible in the form of bar charts.
Relevance of the diagnosis of pharmacogenetics
Why test?
Based on the genetic pattern, there are people who metabolize drugs quickly (fast metabolizers) and therefore do not reach the “therapeutic window” with regard to the effective dose. The drugs can therefore be ineffective because they are underdosed. In contrast, there are slow metabolizers in whom even low doses can lead to toxic events.the PubMed medical database now contains almost one billion publications for the search term “adverse drug effects”.83,054 cases from Germany were reported to the European adverse drug reaction database EudraVigilance in 2019.a dissertation published in 2016 cites an estimated range of 16,000 to 58,000 drug-related deaths in Germany each year.
How DNA is decoded
The PharmaGenes Essentials genetic test uses a polygenic calculation model - this means that all individual contributions of each genetic variant in combination with the environment are taken into account (polygenic effect). The complex algorithm creates an evaluation model based on a large number of variables, i.e. genetic characteristics. The outcome of the evaluation model is more important than the number of genes that may be labeled as altered. No genetic variant should be interpreted individually. The results are presented in bar charts.
Procedure & instructions
1 Meeting between doctor & patient
As a doctor, you can introduce the PharmaGenes Essentials genetic test to your patients and explain the importance of pharmacogenetics to them. If a patient wants to take this genetic test, the entire process goes through the doctor. It is not permitted for a customer to purchase the test independently.
2 Doctor ordered via the order form
The doctor orders the PharmaGenes Essentials genetic test on behalf of his patient using the form linked here for a fee of €370.85 gross and fills it out together with the patient. If you need an English analysis please write it on the form.
The patient's full contact details must be provided (address for the invoice & e-mail address for sending the invoice). The doctor's practice serves as the delivery address.
The form must be signed by both the patient and the doctor and can then be sent to bestellung@mitocare.de to order the chargeable PharmaGenes Essentials genetic test from MITOcare.
Our customer service will contact the doctor and the patient (e-mail in CC) with an order confirmation and further payment processing. The order is sent to the patient by purchase on account for €370.85 gross.
3 Sending the test to the doctor
Once the order has been received, MITOcare will send the genetic test within 3 working days. The genetic test will be sent to the doctor's practice. We will forward the tracking link by e-mail. We cannot influence the speed of the parcel service providers.
4 Checking the order for completeness
The following parts should be included in the shipping box supplied:
• 1 instruction manual
• 1 declaration of consent
• 1 prepaid plastic return bag
• Closure clips for the return envelope
• Packet with swab tubes & throat swabs for saliva collection
• Including biohazard transport bag with absorbent cloth
5 Making an appointment with the patient
The doctor should make an appointment with the patient for the test to be carried out in the practice
6 Read the instructions carefully
Doctor & patient should read the instructions (click here - German)carefully & completely before starting.
7 Carry out a saliva sample
In order to provide a usable saliva sample, the patient should follow the instructions exactly according to the steps given. The sample is then sent as described in the instructions. Important: The recipient address of the result is the doctor's address
8 Analysis of the DNA
After reaching the laboratory, the saliva sample is carefully analyzed & evaluated according to a complex algorithm. This can take up to 10 working days. The findings are then sent in printed form to the practice address provided.
9 Discussion of the results
The doctor will receive a folder by post with the results of the PharmaGenes Essentials genetic test and a Pharma Passport for the patient. The doctor should then make an appointment to discuss the results with the patient. At the appointment, the doctor will hand over the documents, explain the evaluation and, if necessary, adjust the dosage of any medication already prescribed to the result. The doctor should also make a note of the results in the patient's file. The patient can always carry the Pharma-Pass with them so that all information is to hand in an emergency.
1 Meeting between doctor & patient
As a doctor, you can introduce the PharmaGenes Essentials genetic test to your patients and explain the importance of pharmacogenetics to them. If a patient wants to take this genetic test, the entire process goes through the doctor. It is not permitted for a customer to purchase the test independently.
2 Doctor ordered via the order form
The doctor orders the PharmaGenes Essentials genetic test on behalf of his patient using the form linked here for a fee of €370.85 gross and fills it out together with the patient. If you need an English analysis please write it on the form.
The patient's full contact details must be provided (address for the invoice & e-mail address for sending the invoice). The doctor's practice serves as the delivery address.
The form must be signed by both the patient and the doctor and can then be sent to bestellung@mitocare.de to order the chargeable PharmaGenes Essentials genetic test from MITOcare.
Our customer service will contact the doctor and the patient (e-mail in CC) with an order confirmation and further payment processing. The order is sent to the patient by purchase on account for €370.85 gross.
3 Sending the test to the doctor
Once the order has been received, MITOcare will send the genetic test within 3 working days. The genetic test will be sent to the doctor's practice. We will forward the tracking link by e-mail. We cannot influence the speed of the parcel service providers.
4 Checking the order for completeness
The following parts should be included in the shipping box supplied:
• 1 instruction manual
• 1 declaration of consent
• 1 prepaid plastic return bag
• Closure clips for the return envelope
• Packet with swab tubes & throat swabs for saliva collection
• Including biohazard transport bag with absorbent cloth
5 Making an appointment with the patient
The doctor should make an appointment with the patient for the test to be carried out in the practice
6 Read the instructions carefully
Doctor & patient should read the instructions (click here - German)carefully & completely before starting.
7 Carry out a saliva sample
In order to provide a usable saliva sample, the patient should follow the instructions exactly according to the steps given. The sample is then sent as described in the instructions. Important: The recipient address of the result is the doctor's address
8 Analysis of the DNA
After reaching the laboratory, the saliva sample is carefully analyzed & evaluated according to a complex algorithm. This can take up to 10 working days. The findings are then sent in printed form to the practice address provided.
9 Discussion of the results
The doctor will receive a folder by post with the results of the PharmaGenes Essentials genetic test and a Pharma Passport for the patient. The doctor should then make an appointment to discuss the results with the patient. At the appointment, the doctor will hand over the documents, explain the evaluation and, if necessary, adjust the dosage of any medication already prescribed to the result. The doctor should also make a note of the results in the patient's file. The patient can always carry the Pharma-Pass with them so that all information is to hand in an emergency.
Important
This genetic test has been developed for use as a professional tool for doctors and healthcare professionals. The knowledge gained can help to determine a personalized treatment, always taking care to increase efficacy while minimizing the risk of side effects.
This test and the results obtained do not claim to be a substitute for professional medical advice and treatment. The results of this genetic test do not depend on the physical, clinical or therapeutic condition of the person tested.
Disclaimer
Lifestyle genetics is a field of genetics that studies the relationship between genes and individual traits that affect a healthy lifestyle. The use of genetic predisposition information to create a dietary plan should be combined with information on physical characteristics (e.g. age, gender, etc.) and behavioral information (e.g. eating habits, physical activity, etc.). The results of the genetic test cannot be used for clinical diagnosis, disease prevention or assessment of a clinical condition. The result of the genetic test is not dependent on the physical or clinical condition or therapy management of the person tested.
FAQs
Still have questions about the PharmaGenes Essentials genetic test? Perhaps our FAQs can help. If you have any further questions, please contact us by e-mail.
How is the DNA test done? With saliva, blood or hair?
The PharmaGenes Essentials genetic test is carried out using a saliva test.
How often can such a test be carried out?
The PharmaGenes Essentials genetic test only needs to be carried out once in a lifetime.
What exactly is the result?
The PharmaGenes Essentials genetic test has an accuracy of 99%.
Why is such a test useful?
The individual effect of medication depends on the individual genetic predisposition. Genetic variants in proteins with pharmacological significance, such as enzymes, transport proteins and receptors, can influence the metabolism, transport and target structures of medication. This can alter the efficacy and tolerability of medication.
What is analyzed in this genetic test?
The PharmaGenes Essentials genetic test analyzes pharmacogenetics - the DNA and 22 genetic variants with an influence on drug metabolism.
Genes analyzed:
- CYP2D6
Substrates: Antihypertensives, beta-blockers, tricyclic antidepressants, selective serotonin reuptake inhibitors, selective noradrenaline/dopamine reuptake inhibitors, antipsychotics, antiarrhythmics, amphetamines, antiemetics, general substrates, prodrugs (codeine, tamoxifen)
Inhibitors: Bupropion, fluoxetine, paroxetine, etc.
Inducers: dexamethasone, rifampicin - CYP2C9
Substrates: proton pump inhibitors, barbiturates, antiepileptics, benzodiazepines, tricyclic antidepressants, SSRIs, MAO inhibitors, antipsychotics, clozapine, platelet aggregation inhibitors, NSAIDs, cytostatics
Inhibitors: Fluvoxamine, ticlopidine, etc.
Inducers: carbamazepine, prednisone, rifampicin - CYP2C19
Substrates: NSAIDs, Cox2 inhibitors, antihypertensives, angiotensin II blockers, oral antidiabetics, statins, anticoagulants
Inhibitors: Sulfaphenazole and others Inducers: Rifampicin SLCO1B1
Substrates: Atorvastatin, Simvastatin
How can the results be used?
With the results, you can find out the patient's drug metabolism type and can then adapt the patient's medication to their genetic profile. This prevents the patient from receiving either an overdose or an underdose of medication.
Can both Pharma Tests be combined?
If you order PharmaGenes Advanced, there is no point in ordering PharmaGenes Essentials, as PharmaGenes Advanced contains everything that is covered by Essentials. Essentials is suitable for people who only take a few medications, the corresponding medications are listed in the PharmaGenes Essentials sample report.
