Themen dieses Blogartikels:
Introduction
Turmeric and curcumin - what's the difference?
What is curcumin good for?
Curcumin as antioxidant
Ideally, your body can maintain a good balance, but if several stressors come together, the level of stress can be so high that the cell is fundamentally disrupted and even dies. Curcumin has proven to be a powerful antioxidant1 and is therefore often used to maintain or restore balance. Curcumin may be particularly recommended for people who also have problems with their mitochondria, the energy power plants. It is precisely here, in the mitochondria, that the majority of free radicals are produced. In this context, it has even been shown that curcumin not only neutralizes free radicals, but can also promote the body's own neutralizing systems and enzymes, in particular the enzymes SOD (superoxide dismutase) and catalase2.
Does curcumin reduce inflammation?
The best way to understand this is probably with a concrete example: so-called prostaglandins have a largely pro-inflammatory effect and are produced in greater quantities during inflammation. They are produced by the enzyme COX (cyclooxygenase). You may be familiar with this enzyme, as it is the starting point for many medications, including Aspirin®. Curcumin can also inhibit this enzyme or cause it to be formed less1,4.
In the case of osteoarthritis, i.e. inflammation of the bones and joints, an analysis of various studies has shown that curcumin can reduce joint pain and the consumption of painkillers5. In addition, basic research shows that inflammatory pathways are inhibited and thus diseases such as osteoarthritis could be influenced. Of course, more studies are needed before a definitive statement can be made, but the results so far indicate that curcumin helps with diseases such as osteoarthritis.
Let's summarize briefly: Curcumin has many possible effects, especially antioxidant and anti-inflammatory effects are significant for the everyday and therapeutic use of the plant substance. So curcumin is definitely healthy.
Curcumin - potential future opportunities?
Is curcumin safe?
How much curcumin a day is optimal?
Which curcumin is the best?
Curcumin with piperine from black pepper
Does micelle technology increase curcumin bioavailability?
Liposomal curcumin - currently the best option?
The big advantage: in contrast to micelles, polysorbate 80 can be dispensed with in liposomes and preserved naturally instead.
Is curcumin in nanoparticles the future?
For now, I definitely recommend liposomal curcumin, which has proven to be very well tolerated and bioavailable.
Capsules, powder or liquid - how should I take curcumin?
The relevance of curcumin for athletes
This article is based on study-based research & careful quality check
Bibliography
1 Menon, V. P. & Sudheer, A. R. (2007). Antioxidant and anti-inflammatory properties of curcumin. Advances in experimental medicine and biology, 595, 105–125.
2 Abrahams, S., Haylett, W. L., Johnson, G., Carr, J. A. & Bardien, S. (2019). Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: A review. Neuroscience, 406, 1–21.
3 Ferguson, J. J. A., Abbott, K. A., & Garg, M. L. (2021). Anti-inflammatory effects of oral supplementation with curcumin: a systematic review and meta-analysis of randomized controlled trials. Nutrition reviews, 79(9), 1043–1066.
4 Rao C. V. (2007). Regulation of COX and LOX by curcumin. Advances in experimental medicine and biology, 595, 213–226.
5 Chin K. Y. (2016). The spice for joint inflammation: anti-inflammatory role of curcumin in treating osteoarthritis. Drug design, development and therapy, 10, 3029–3042.
6 Reuter, S., Eifes, S., Dicato, M., Aggarwal, B. B., & Diederich, M. (2008). Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells. Biochemical pharmacology, 76(11), 1340–1351.
7 Soleimani, V., Sahebkar, A., & Hosseinzadeh, H. (2018). Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review. Phytotherapy research : PTR, 32(6), 985–995.
8 Lao, C. D., Ruffin, M. T., 4th, Normolle, D., Heath, D. D., Murray, S. I., Bailey, J. M., Boggs, M. E., Crowell, J., Rock, C. L., & Brenner, D. E. (2006). Dose escalation of a curcuminoid formulation. BMC complementary and alternative medicine, 6, 10.
9 Hassanzadeh, K., Buccarello, L., Dragotto, J., Mohammadi, A., Corbo, M., & Feligioni, M. (2020). Obstacles against the Marketing of Curcumin as a Drug. International journal of molecular sciences, 21(18), 6619.
10 Hegde, M., Girisa, S., BharathwajChetty, B., Vishwa, R., & Kunnumakkara, A. B. (2023). Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?. ACS omega, 8(12), 10713–10746.
11 Cuomo, J., Appendino, G., Dern, A. S., Schneider, E., McKinnon, T. P., Brown, M. J., Togni, S., & Dixon, B. M. (2011). Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation. Journal of natural products, 74(4), 664–669.